Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR

G-protein-coupled receptors (GPCRs) mostly signal through heterotrimeric G proteins. Increasing evidence suggests that GPCRs could function in a G-protein-independent manner. Here, we show that at low concentrations of an agonist, β(2)-adrenergic receptors (β(2)-ARs) signal through Gα(s) to activate...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Sun, Yutong, Huang, Jianyun, Xiang, Yang, Bastepe, Murat, Jüppner, Harald, Kobilka, Brian K, Zhang, J Jillian, Huang, Xin-Yun
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2007
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782364/
https://ncbi.nlm.nih.gov/pubmed/17170700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601502
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki