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Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV
Endonuclease IV belongs to a class of important apurinic/apyrimidinic endonucleases involved in DNA repair. Although a structure-based mechanistic hypothesis has been put forth for this enzyme, the detailed catalytic mechanism has remained unknown. Using thermodynamic integration in the context of a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1780068/ https://ncbi.nlm.nih.gov/pubmed/17242363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603468104 |
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