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Preservation of Photoreceptor Morphology and Function in P23H Rats Using an Allele Independent Ribozyme
To develop an allele independent ribozyme for the treatment of Autosomal Dominant Retinitis Pigmentosa (ADRP) associated with mutations in the rhodopsin (RHO) gene. A ribozyme targeting dog, mouse, human but not rat rhodopsin (RHO) mRNA was designed and tested in vitro. Activity of this ribozyme was...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2006
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1778459/ https://ncbi.nlm.nih.gov/pubmed/17083931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2006.08.014 |
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