Functional Rescue of P23H Rhodopsin Photoreceptors by Gene Delivery

The mechanism of autosomal dominant retinitis pigmentosa (ADRP) caused by the P23H mutation in rhodopsin is tightly associated with misfolded rhodopsin (RHO) which causes endoplasmic reticulum overload (ER stress), activates the unfolded protein response (UPR) and triggers apoptosis. In efforts to c...

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Detaylı Bibliyografya
Asıl Yazarlar: Gorbatyuk, Marina S., Gorbatyuk, Oleg S., LaVail, Matthew M., Lin, Jonathan H., Hauswirth, William W., Lewin, Alfred S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365920/
https://ncbi.nlm.nih.gov/pubmed/22183333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4614-0631-0_26
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