Functional Rescue of P23H Rhodopsin Photoreceptors by Gene Delivery

The mechanism of autosomal dominant retinitis pigmentosa (ADRP) caused by the P23H mutation in rhodopsin is tightly associated with misfolded rhodopsin (RHO) which causes endoplasmic reticulum overload (ER stress), activates the unfolded protein response (UPR) and triggers apoptosis. In efforts to c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gorbatyuk, Marina S., Gorbatyuk, Oleg S., LaVail, Matthew M., Lin, Jonathan H., Hauswirth, William W., Lewin, Alfred S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365920/
https://ncbi.nlm.nih.gov/pubmed/22183333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4614-0631-0_26
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