Functional Rescue of P23H Rhodopsin Photoreceptors by Gene Delivery

The mechanism of autosomal dominant retinitis pigmentosa (ADRP) caused by the P23H mutation in rhodopsin is tightly associated with misfolded rhodopsin (RHO) which causes endoplasmic reticulum overload (ER stress), activates the unfolded protein response (UPR) and triggers apoptosis. In efforts to c...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gorbatyuk, Marina S., Gorbatyuk, Oleg S., LaVail, Matthew M., Lin, Jonathan H., Hauswirth, William W., Lewin, Alfred S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365920/
https://ncbi.nlm.nih.gov/pubmed/22183333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4614-0631-0_26
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