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Functional Rescue of P23H Rhodopsin Photoreceptors by Gene Delivery
The mechanism of autosomal dominant retinitis pigmentosa (ADRP) caused by the P23H mutation in rhodopsin is tightly associated with misfolded rhodopsin (RHO) which causes endoplasmic reticulum overload (ER stress), activates the unfolded protein response (UPR) and triggers apoptosis. In efforts to c...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3365920/ https://ncbi.nlm.nih.gov/pubmed/22183333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4614-0631-0_26 |
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