Functional Rescue of P23H Rhodopsin Photoreceptors by Gene Delivery

The mechanism of autosomal dominant retinitis pigmentosa (ADRP) caused by the P23H mutation in rhodopsin is tightly associated with misfolded rhodopsin (RHO) which causes endoplasmic reticulum overload (ER stress), activates the unfolded protein response (UPR) and triggers apoptosis. In efforts to c...

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Bibliografiske detaljer
Main Authors: Gorbatyuk, Marina S., Gorbatyuk, Oleg S., LaVail, Matthew M., Lin, Jonathan H., Hauswirth, William W., Lewin, Alfred S.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365920/
https://ncbi.nlm.nih.gov/pubmed/22183333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4614-0631-0_26
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