Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn’s disease

Background: Nucleotide binding oligomerisation domain 2 (NOD2; also known as CARD15) mutations are associated with Crohn’s disease but how mutations cause disease is poorly understood. Innate immune responses are reportedly enhanced by combined NOD2 ligand (muramyl dipeptide, MDP) and Toll-like rece...

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Autores principales: van Heel, D A, Ghosh, S, Hunt, K A, Mathew, C G, Forbes, A, Jewell, D P, Playford, R J
Formato: Artigo
Lenguaje:Inglês
Publicado: Copyright 2005 by Gut 2005
Materias:
Inflammatory Bowel Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774767/
https://ncbi.nlm.nih.gov/pubmed/15928043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2005.065888
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