Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn’s disease

Background: Nucleotide binding oligomerisation domain 2 (NOD2; also known as CARD15) mutations are associated with Crohn’s disease but how mutations cause disease is poorly understood. Innate immune responses are reportedly enhanced by combined NOD2 ligand (muramyl dipeptide, MDP) and Toll-like rece...

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Detalhes bibliográficos
Main Authors: van Heel, D A, Ghosh, S, Hunt, K A, Mathew, C G, Forbes, A, Jewell, D P, Playford, R J
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2005 by Gut 2005
Assuntos:
Inflammatory Bowel Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774767/
https://ncbi.nlm.nih.gov/pubmed/15928043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2005.065888
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