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Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis
Thrombin, a central mediator of hemostasis and thrombosis, converts fibrinogen to fibrin and is a potent platelet activator. Activated platelets provide a surface for assembly of the tenase and prothrombinase complexes required for thrombin generation. The role of thrombin-induced platelet activatio...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1765451/ https://ncbi.nlm.nih.gov/pubmed/17190826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610188104 |
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