Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact

T cell differentiation in the thymus is driven by positive selection through the interaction of αβ T cell receptors (TCRs) with self-peptides bound to self-major histocompatibility complex molecules, yet the influence of the peptide sequence on this process remains unknown. To address this issue, we...

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Bibliographic Details
Main Authors: Fukui, Yoshinori, Oono, Takamasa, Cabaniols, Jean-Pierre, Nakao, Kazuki, Hirokawa, Katsuiku, Inayoshi, Ayumi, Sanui, Terukazu, Kanellopoulos, Jean, Iwata, Eiko, Noda, Mayuko, Katsuki, Motoya, Kourilsky, Philippe, Sasazuki, Takehiko
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2000
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC17649/
https://ncbi.nlm.nih.gov/pubmed/11087837
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