Directed biosynthesis of new saframycin derivatives with resting cells of Streptomyces lavendulae.

Saframycin A is an antitumor antibiotic produced by Streptomyces lavendulae 314 which falls into the category of the N-heterocyclic quinone group. Biosynthetically the quinone ring is derived from two tyrosine molecules which condense to generate the basic ring system of saframycin A. The side chain...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Arai, T, Yazawa, K, Takahashi, K, Maeda, A, Mikami, Y
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1985
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC176299/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3839995/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.28.1.5
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