Aneuploidy Arises at Early Stages of Apc-Driven Intestinal Tumorigenesis and Pinpoints Conserved Chromosomal Loci of Allelic Imbalance between Mouse and Human

Although chromosomal instability characterizes the majority of human colorectal cancers, the contribution of genes such as adenomatous polyposis coli (APC), KRAS, and p53 to this form of genetic instability is still under debate. Here, we have assessed chromosomal imbalances in tumors from mouse mod...

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Detalhes bibliográficos
Main Authors: Alberici, Paola, de Pater, Emma, Cardoso, Joana, Bevelander, Mieke, Molenaar, Lia, Jonkers, Jos, Fodde, Riccardo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762685/
https://ncbi.nlm.nih.gov/pubmed/17200209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060853
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