Mutational Heterogeneity in APC and KRAS Arises at the Crypt level and Leads to Polyclonality in Early Colorectal Tumorigenesis

PURPOSE: The majority of genomic alterations causing intratumoral heterogeneity (ITH) in colorectal cancer (CRC) are thought to arise during early stages of carcinogenesis as a burst but only after truncal mutations in APC have expanded a single founder clone. We have investigated if the initial sou...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Gausachs, Mireia, Borras, Ester, Chang, Kyle, Gonzalez, Sara, Azuara, Daniel, Amador, Axel Delgado, Lopez-Doriga, Adriana, San Lucas, F. Anthony, Sanjuan, Xavier, Paules, Maria Jose, Taggart, Melissa W., Davies, Gareth E., Ehli, Erik A., Fowler, Jerry, Moreno, Victor, Pineda, Marta, You, Y. Nancy, Lynch, Patrick M., Lazaro, Conxi, Navin, Nicholas E., Scheet, Paul A., Hawk, Ernest T., Capella, Gabriel, Vilar, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626604/
https://ncbi.nlm.nih.gov/pubmed/28645942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0821
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