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Studies of Optineurin, a Glaucoma Gene : Golgi Fragmentation and Cell Death from Overexpression of Wild-Type and Mutant Optineurin in Two Ocular Cell Types

Optineurin (OPTN) has recently been linked to glaucoma, a major cause of blindness worldwide. Mutations in OPTN such as Glu(50)→Lys (E50K) have been reported in patients, particularly those with normal pressure glaucoma. Here, we show that the endogenous OPTN was not secreted in two ocular cell type...

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Detalles Bibliográficos
Main Authors: Park, Bum-Chan, Shen, Xiang, Samaraweera, Mishan, Yue, Beatrice Y.J.T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762487/
https://ncbi.nlm.nih.gov/pubmed/17148662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060400
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