Separation of Anti-Proliferation and Anti-Apoptotic Functions of Retinoblastoma Protein through Targeted Mutations of Its A/B Domain

BACKGROUND: The human retinoblastoma susceptibility gene encodes a nuclear phosphoprotein RB, which is a negative regulator of cell proliferation. The growth suppression function of RB requires an evolutionarily conserved A/B domain that contains two distinct peptide-binding pockets. At the A/B inte...

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Bibliographische Detailangaben
Hauptverfasser: Chau, B. Nelson, Pan, Chris W., Wang, Jean Y.J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1762320/
https://ncbi.nlm.nih.gov/pubmed/17183714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000082
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