Ryanodine receptors are targeted by anti-apoptotic Bcl-X(L) involving its BH4 domain and Lys87 from its BH3 domain

Anti-apoptotic B-cell lymphoma 2 (Bcl-2) family members target several intracellular Ca(2+)-transport systems. Bcl-2, via its N-terminal Bcl-2 homology (BH) 4 domain, inhibits both inositol 1,4,5-trisphosphate receptors (IP(3)Rs) and ryanodine receptors (RyRs), while Bcl-X(L), likely independently o...

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Udgivet i:Sci Rep
Main Authors: Vervliet, Tim, Lemmens, Irma, Vandermarliere, Elien, Decrock, Elke, Ivanova, Hristina, Monaco, Giovanni, Sorrentino, Vincenzo, Kasri, Nael Nadif, Missiaen, Ludwig, Martens, Lennart, De Smedt, Humbert, Leybaert, Luc, Parys, Jan B., Tavernier, Jan, Bultynck, Geert
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397538/
https://ncbi.nlm.nih.gov/pubmed/25872771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09641
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