Selective regulation of IP(3)-receptor-mediated Ca(2+) signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl

Antiapoptotic B-cell lymphoma 2 (Bcl-2) targets the inositol 1,4,5-trisphosphate receptor (IP(3)R) via its BH4 domain, thereby suppressing IP(3)R Ca(2+)-flux properties and protecting against Ca(2+)-dependent apoptosis. Here, we directly compared IP(3)R inhibition by BH4-Bcl-2 and BH4-Bcl-Xl. In con...

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Detalhes bibliográficos
Main Authors: Monaco, G, Decrock, E, Akl, H, Ponsaerts, R, Vervliet, T, Luyten, T, De Maeyer, M, Missiaen, L, Distelhorst, C W, De Smedt, H, Parys, J B, Leybaert, L, Bultynck, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263504/
https://ncbi.nlm.nih.gov/pubmed/21818117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.97
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