Protein folding and unfolding in microseconds to nanoseconds by experiment and simulation

The Engrailed Homeodomain protein has the highest refolding and unfolding rate constants directly observed to date. Temperature jump relaxation measurements gave a refolding rate constant of 37,500 s(−1) in water at 25°C, rising to 51,000 s(−1) around 42°C. The unfolding rate constant was 1,100 s(−1...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Mayor, Ugo, Johnson, Christopher M., Daggett, Valerie, Fersht, Alan R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17607/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11087839/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.250473497
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