Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice.
Malarial parasites, in contrast to mammalian cells, utilize orotic acid more efficiently than uracil or uridine. Recently, chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum were shown to be inhibited by 5-fluoroorotate, with a 50% inhibitory concentration of 6 nM in v...
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| Publicado no: | Antimicrob Agents Chemother |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC175983/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2386369/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.7.1371 |
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