Effects of moderate renal insufficiency on pharmacokinetics of methotrexate in rheumatoid arthritis patients

OBJECTIVES—To determine the effects of impaired renal function on the pharmacokinetics of methotrexate (MTX) in rheumatoid arthritis (RA) patients.
METHODS—77 RA patients were included in this study. MTX was administered intramuscularly (7.5 to 15 mg). Subjects were divided into four groups, accordi...

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Hlavní autoři: Bressolle, F, Bologna, C, Kinowski, J, Sany, J, Combe, B
Médium: Artigo
Jazyk:Inglês
Vydáno: 1998
Témata:
Concise Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1752537/
https://ncbi.nlm.nih.gov/pubmed/9613341
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