Effects of moderate renal insufficiency on pharmacokinetics of methotrexate in rheumatoid arthritis patients

OBJECTIVES—To determine the effects of impaired renal function on the pharmacokinetics of methotrexate (MTX) in rheumatoid arthritis (RA) patients.
METHODS—77 RA patients were included in this study. MTX was administered intramuscularly (7.5 to 15 mg). Subjects were divided into four groups, accordi...

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Detalles Bibliográficos
Main Authors: Bressolle, F, Bologna, C, Kinowski, J, Sany, J, Combe, B
Formato: Artigo
Idioma:Inglês
Publicado: 1998
Assuntos:
Concise Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1752537/
https://ncbi.nlm.nih.gov/pubmed/9613341
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