A structural snapshot of an intermediate on the streptavidin–biotin dissociation pathway

It is currently unclear whether small molecules dissociate from a protein binding site along a defined pathway or through a collection of dissociation pathways. We report herein a joint crystallographic, computational, and biophysical study that suggests the Asp-128 → Ala (D128A) streptavidin mutant...

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Main Authors: Freitag, Stefanie, Chu, Vano, Penzotti, Julie E., Klumb, Lisa A., To, Richard, Hyre, David, Le Trong, Isolde, Lybrand, Terry P., Stenkamp, Ronald E., Stayton, Patrick S.
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1999
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC17525/
https://ncbi.nlm.nih.gov/pubmed/10411884
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