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Dynamics of the streptavidin-biotin complex in solution and in its crystal lattice: Distinct behavior revealed by molecular simulations

We present a 250ns simulation of the wild-type, biotin-liganded streptavidin tetramer in the solution phase and compare the trajectory to two previously published simulations of the protein in its crystal lattice. By performing both types of simulations, we are able to interpret the protein’s behavi...

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Detalhes bibliográficos
Main Authors: Cerutti, David S., Trong, Isolde Le, Stenkamp, Ronald E., Lybrand, Terry P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791092/
https://ncbi.nlm.nih.gov/pubmed/19374419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp9010372
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