Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1

Transient receptor potential vanilloid 1 (TRPV1), a ligand-gated cation channel highly expressed in small-diameter sensory neurons, is activated by heat, protons, and capsaicin. The phosphorylation of TRPV1 provides a versatile regulation of intracellular calcium levels and is critical for TRPV1 fun...

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Hlavní autoři: Pareek, Tej K., Keller, Jason, Kesavapany, Sashi, Agarwal, Nitin, Kuner, Rohini, Pant, Harish C., Iadarola, Michael J., Brady, Roscoe O., Kulkarni, Ashok B.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1752192/
https://ncbi.nlm.nih.gov/pubmed/17194758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609916104
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