Modulation of P-glycoprotein activity by cannabinoid molecules in HK-2 renal cells

1. Endogenous and synthetic cannabinoid molecules have been investigated as possible MDR-1/P-glycoprotein (P-gp) modulators in HK-2-immortalized renal cells, using calcein acetoxymethylester (calcein-AM) as a P-gp substrate. 2. Among the endocannabinoid molecules tested, anandamide (AEA), but not 2-...

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Bibliografiske detaljer
Main Authors: Nieri, Paola, Romiti, Nadia, Adinolfi, Barbara, Chicca, Andrea, Massarelli, Ilaria, Chieli, Elisabetta
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2006
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Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751877/
https://ncbi.nlm.nih.gov/pubmed/16715117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706778
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