Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets

1. Incorporation of a nitric oxide (NO)-releasing moiety in aspirin can overcome its gastric side effects. 2. We investigated the NO-release patterns and antiplatelet effects of novel furoxan derivatives of aspirin (B8 and B7) in comparison to existing antiplatelet agents. 3. Cyclooxygenase (COX) ac...

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Bibliographic Details
Main Authors: Turnbull, Catriona M, Cena, Clara, Fruttero, Roberta, Gasco, Alberto, Rossi, Adriano G, Megson, Ian L
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2006
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1751793/
https://ncbi.nlm.nih.gov/pubmed/16702997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706743
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