A novel hybrid aspirin-NO-releasing compound inhibits TNFalpha release from LPS-activated human monocytes and macrophages

BACKGROUND: The cytoprotective nature of nitric oxide (NO) led to development of NO-aspirins in the hope of overcoming the gastric side-effects of aspirin. However, the NO moiety gives these hybrids potential for actions further to their aspirin-mediated anti-platelet and anti-inflammatory effects....

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Autors principals: Turnbull, Catriona M, Marcarino, Paolo, Sheldrake, Tara A, Lazzarato, Loretta, Cena, Clara, Fruttero, Roberta, Gasco, Alberto, Fox, Sarah, Megson, Ian L, Rossi, Adriano G
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2008
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525633/
https://ncbi.nlm.nih.gov/pubmed/18671842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-5-12
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