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FAK Potentiates Rac1 Activation and Localization to Matrix Adhesion Sites: A Role for βPIX
FAK, a cytoplasmic protein tyrosine kinase, is activated and localized to focal adhesions upon cell attachment to extracellular matrix. FAK null cells spread poorly and exhibit altered focal adhesion turnover. Rac1 is a member of the Rho-family GTPases that promotes membrane ruffling, leading edge e...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Cell Biology
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1751318/ https://ncbi.nlm.nih.gov/pubmed/17093062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-03-0207 |
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