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Amyloid of the prion domain of Sup35p has an in-register parallel β-sheet structure

The [PSI(+)] prion of Saccharomyces cerevisiae is a self-propagating amyloid form of Sup35p, a subunit of the translation termination factor. Using solid-state NMR we have examined the structure of amyloid fibrils formed in vitro from purified recombinant Sup35(1–253), consisting of the glutamine- a...

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Библиографические подробности
Главные авторы: Shewmaker, Frank, Wickner, Reed B., Tycko, Robert
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1750918/
https://ncbi.nlm.nih.gov/pubmed/17170131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609638103
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