Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity.

In vitro and in vivo studies were done on a herpes simplex virus type 2 strain recovered from a patient on acyclovir (ACV) which was ACV resistant but expressed thymidine (dThd) kinase (EC 2.7.1.21) activity. Plaque-purified clones derived from the original clinical sample were heterogeneous with re...

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Main Authors: Ellis, M N, Keller, P M, Fyfe, J A, Martin, J L, Rooney, J F, Straus, S E, Lehrman, S N, Barry, D W
Formato: Artigo
Idioma:Inglês
Publicado: 1987
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC174881/
https://ncbi.nlm.nih.gov/pubmed/2821890
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