Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity.

In vitro and in vivo studies were done on a herpes simplex virus type 2 strain recovered from a patient on acyclovir (ACV) which was ACV resistant but expressed thymidine (dThd) kinase (EC 2.7.1.21) activity. Plaque-purified clones derived from the original clinical sample were heterogeneous with re...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Ellis, M N, Keller, P M, Fyfe, J A, Martin, J L, Rooney, J F, Straus, S E, Lehrman, S N, Barry, D W
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174881/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2821890/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.7.1117
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