Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange

Regional alveolar hypoxia causes local vasoconstriction in the lung, shifting blood flow from hypoxic to normoxic areas, thereby maintaining gas exchange. This mechanism is known as hypoxic pulmonary vasoconstriction (HPV). Disturbances in HPV can cause life-threatening hypoxemia whereas chronic hyp...

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Hauptverfasser: Weissmann, Norbert, Dietrich, Alexander, Fuchs, Beate, Kalwa, Hermann, Ay, Mahmut, Dumitrascu, Rio, Olschewski, Andrea, Storch, Ursula, Mederos y Schnitzler, Michael, Ghofrani, Hossein Ardeschir, Schermuly, Ralph Theo, Pinkenburg, Olaf, Seeger, Werner, Grimminger, Friedrich, Gudermann, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1748182/
https://ncbi.nlm.nih.gov/pubmed/17142322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606728103
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