Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice

Lung ischaemia–reperfusion-induced oedema (LIRE) is a life-threatening condition that causes pulmonary oedema induced by endothelial dysfunction. Here we show that lungs from mice lacking nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox2(y/−)) or the classical transient receptor pote...

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Autori principali: Weissmann, Norbert, Sydykov, Akylbek, Kalwa, Hermann, Storch, Ursula, Fuchs, Beate, Schnitzler, Michael Mederos y, Brandes, Ralf P., Grimminger, Friedrich, Meissner, Marcel, Freichel, Marc, Offermanns, Stefan, Veit, Florian, Pak, Oleg, Krause, Karl-Heinz, Schermuly, Ralph T., Brewer, Alison C, Schmidt, Harald H.H.W., Seeger, Werner, Shah, Ajay M., Gudermann, Thomas, Ghofrani, Hossein A., Dietrich, Alexander
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272568/
https://ncbi.nlm.nih.gov/pubmed/22337127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1660
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