Activity of purine analogs against Leishmania donovani in vivo.

The dose of orally administered 9-deazainosine calculated to suppress 50% of Leishmania donovani amastigotes in hamster livers was 19 mg/kg (body weight) per day; 96 to 99% of Leishmania organisms were eliminated from the liver and spleen of squirrel monkeys by 50 mg/kg per day. Because these activi...

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Bibliographic Details

Published in:	Antimicrob Agents Chemother
Main Authors:	Berman, J D, Hanson, W L, Lovelace, J K, Waits, V B, Jackson, J E, Chapman, W L, Klein, R S
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1987
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174664/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3566235/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.31.1.111
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