Activity of purine analogs against Leishmania donovani in vivo.

The dose of orally administered 9-deazainosine calculated to suppress 50% of Leishmania donovani amastigotes in hamster livers was 19 mg/kg (body weight) per day; 96 to 99% of Leishmania organisms were eliminated from the liver and spleen of squirrel monkeys by 50 mg/kg per day. Because these activi...

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Autores principales: Berman, J D, Hanson, W L, Lovelace, J K, Waits, V B, Jackson, J E, Chapman, W L, Klein, R S
Formato: Artigo
Lenguaje:Inglês
Publicado: 1987
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC174664/
https://ncbi.nlm.nih.gov/pubmed/3566235
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