Substitution of cysteine 192 in a highly conserved Streptococcus pyogenes extracellular cysteine protease (interleukin 1beta convertase) alters proteolytic activity and ablates zymogen processing.
Virtually all strains of the human pathogenic bacterium Streptococcus pyogenes express a highly conserved extracellular cysteine protease. The protein is made as an inactive zymogen of 40,000 Da and undergoes autocatalytic truncation to result in a 28,000-Da active protease. Numerous independent lin...
Tallennettuna:
| Julkaisussa: | Infect Immun |
|---|---|
| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Microbiology (ASM)
1996
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174016/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8675287/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.64.6.1913-1917.1996 |
| Tagit: |
Ei tageja, Lisää ensimmäinen tagi!
|