Characterization of recombinant tetanus toxin derivatives suitable for vaccine development.

Recombinant derivatives of tetanus toxin (TeTx) were isolated and used to immunize mice. Recombinant TeTx light chain, a derivative of fragment C that had lost the ability to bind neurons, and a recombinant TeTx holotoxoid that could protect mice against TeTx challenge were identified.

Dades bibliogràfiques

Publicat a:	Infect Immun
Autors principals:	Figueiredo, D, Turcotte, C, Frankel, G, Li, Y, Dolly, O, Wilkin, G, Marriott, D, Fairweather, N, Dougan, G
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1995
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC173441/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7622252/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.63.8.3218-3221.1995
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