Binding sites in Escherichia coli dihydrofolate reductase communicate by modulating the conformational ensemble
To explore how distal mutations affect binding sites and how binding sites in proteins communicate, an ensemble-based model of the native state was used to define the energetic connectivities between the different structural elements of Escherichia coli dihydrofolate reductase. Analysis of this mode...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2000
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17287/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11035796/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.220240297 |
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