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Cytochrome c binding to Apaf-1: The effects of dATP and ionic strength

In the apoptosis pathway in mammals, cytochrome c and dATP are critical cofactors in the activation of caspase 9 by Apaf-1. Until now, the detailed sequence of events in which these cofactors interact has been unclear. Here, we show through fluorescence polarization experiments that cytochrome c can...

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Bibliografiske detaljer
Main Authors: Purring-Koch, Cherie, McLendon, George
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC17271/
https://ncbi.nlm.nih.gov/pubmed/11035811
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