Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers

We characterized antigen-specific CD4(+) T cells in six patients with treatment-resistant Lyme arthritis, using an HLA-DRB1*0401 major histocompatibility complex (MHC) class II tetramer covalently loaded with OspA(164–175), an immunodominant epitope of Borrelia burgdorferi. Direct analysis of OspA-t...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Meyer, Abbie L., Trollmo, Christina, Crawford, Frances, Marrack, Philippa, Steere, Allen C., Huber, Brigitte T., Kappler, John, Hafler, David A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC17217/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11005833/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.190335897
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