Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers

We characterized antigen-specific CD4(+) T cells in six patients with treatment-resistant Lyme arthritis, using an HLA-DRB1*0401 major histocompatibility complex (MHC) class II tetramer covalently loaded with OspA(164–175), an immunodominant epitope of Borrelia burgdorferi. Direct analysis of OspA-t...

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Autores principales: Meyer, Abbie L., Trollmo, Christina, Crawford, Frances, Marrack, Philippa, Steere, Allen C., Huber, Brigitte T., Kappler, John, Hafler, David A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2000
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC17217/
https://ncbi.nlm.nih.gov/pubmed/11005833
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