Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and beta-lactam antimicrobial agents.

Norfloxacin, ofloxacin, and other new quinolones, which are antagonists of the enzyme DNA gyrase, rapidly kill bacteria by largely unknown mechanisms. Earlier, we isolated, after mutagenesis, Escherichia coli DS1, which exhibited reduced killing by quinolones. We evaluated the killing of DS1 and sev...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Wolfson, J S, Hooper, D C, McHugh, G L, Bozza, M A, Swartz, M N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171968/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1963289/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.10.1938
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