Mutants of Escherichia coli K-12 exhibiting reduced killing by both quinolone and beta-lactam antimicrobial agents.

Norfloxacin, ofloxacin, and other new quinolones, which are antagonists of the enzyme DNA gyrase, rapidly kill bacteria by largely unknown mechanisms. Earlier, we isolated, after mutagenesis, Escherichia coli DS1, which exhibited reduced killing by quinolones. We evaluated the killing of DS1 and sev...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Wolfson, J S, Hooper, D C, McHugh, G L, Bozza, M A, Swartz, M N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171968/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1963289/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.10.1938
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