Metabolic N-hydroxylation of pentamidine in vitro.

By using high-performance liquid chromatography, the in vitro conversion of pentamidine to the corresponding amidoximes (N-hydroxypentamidine and N,N'-dihydroxypentamidine) was studied in supernatants of rat liver homogenate centrifuged at 9,000 x g. The presence of the two amidoxime peaks in chroma...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Berger, B J, Lombardy, R J, Marbury, G D, Bell, C A, Dykstra, C C, Hall, J E, Tidwell, R R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC171904/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2285279/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.34.9.1678
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