Structure-activity relationships of pentamidine analogs against Giardia lamblia and correlation of antigiardial activity with DNA-binding affinity.

1,5-Di(4-amidinophenoxy)pentane (pentamidine) and 38 analogs of pentamidine were screened for in vitro activity against the enteric protozoan Giardia lamblia WB (ATCC 30957). All compounds were active against G. lamblia as measured by a [methyl-3H]thymidine incorporation assay. Antigiardial activity...

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書誌詳細

出版年:	Antimicrob Agents Chemother
主要な著者:	Bell, C A, Cory, M, Fairley, T A, Hall, J E, Tidwell, R R
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology (ASM) 1991
主題:	Research Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC284294/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1929249/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.35.6.1099
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