Metabolic N-hydroxylation of pentamidine in vitro.

By using high-performance liquid chromatography, the in vitro conversion of pentamidine to the corresponding amidoximes (N-hydroxypentamidine and N,N'-dihydroxypentamidine) was studied in supernatants of rat liver homogenate centrifuged at 9,000 x g. The presence of the two amidoxime peaks in c...

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Main Authors: Berger, B J, Lombardy, R J, Marbury, G D, Bell, C A, Dykstra, C C, Hall, J E, Tidwell, R R
Formato: Artigo
Idioma:Inglês
Publicado: 1990
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC171904/
https://ncbi.nlm.nih.gov/pubmed/2285279
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