Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

Transgenic mice expressing human amyloid precursor proteins (hAPP) and amyloid-β peptides (Aβ) in neurons develop phenotypic alterations resembling Alzheimer's disease (AD). The mechanisms underlying cognitive deficits in AD and hAPP mice are largely unknown. We have identified two molecular al...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Palop, Jorge J., Jones, Brian, Kekonius, Lisa, Chin, Jeannie, Yu, Gui-Qiu, Raber, Jacob, Masliah, Eliezer, Mucke, Lennart
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC170959/
https://ncbi.nlm.nih.gov/pubmed/12881482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1133381100
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky