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Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

Transgenic mice expressing human amyloid precursor proteins (hAPP) and amyloid-β peptides (Aβ) in neurons develop phenotypic alterations resembling Alzheimer's disease (AD). The mechanisms underlying cognitive deficits in AD and hAPP mice are largely unknown. We have identified two molecular al...

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Detalhes bibliográficos
Main Authors: Palop, Jorge J., Jones, Brian, Kekonius, Lisa, Chin, Jeannie, Yu, Gui-Qiu, Raber, Jacob, Masliah, Eliezer, Mucke, Lennart
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC170959/
https://ncbi.nlm.nih.gov/pubmed/12881482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1133381100
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