A four-way junction accelerates hairpin ribozyme folding via a discrete intermediate

The natural form of the hairpin ribozyme comprises two major structural elements: a four-way RNA junction and two internal loops carried by adjacent arms of the junction. The ribozyme folds into its active conformation by an intimate association between the loops, and the efficiency of this process...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Tan, Elliot, Wilson, Timothy J., Nahas, Michelle K., Clegg, Robert M., Lilley, David M. J., Ha, Taekjip
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2003
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC170914/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12883002/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1233536100
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