Role of extracellular subdomains of p185(c-neu) and the epidermal growth factor receptor in ligand-independent association and transactivation

We investigated the assembly and activation of the epidermal growth factor receptor (EGFR)–p185(c-neu) heterodimer by using a sequential immunoprecipitation methodology. Using this approach we detected heterodimers and also higher-ordered oligomeric complexes. Phosphorylated EGFR–p185(c-neu) heterod...

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Bibliographic Details
Main Authors: Kumagai, Toru, Katsumata, Makoto, Hasegawa, Akihiro, Furuuchi, Keiji, Funakoshi, Toshiki, Kawase, Ichiro, Greene, Mark I.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC170899/
https://ncbi.nlm.nih.gov/pubmed/12867596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1633546100
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