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Long-distance conformational changes in a protein engineered by modulated sequence duplication
There are few, if any, known instances in which a biological signal is transmitted via a large conformational change through the body of a protein. We describe here a mutant of T4 lysozyme that was engineered to permit structural change at a distance. The design uses a tandem sequence repeat that ma...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2003
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC170894/ https://ncbi.nlm.nih.gov/pubmed/12869697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1633549100 |
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